Preclinical Study

An in vivo study was performed to establish and validate the bioavailability of organic elemental iron (BioIron) in combination with or without BioPerine®.

The study involved a single oral dose of BioIron with BioPerine® (group I) or BioIron without BioPerine® (group II) administration to rabbits,  and blood samples  were collected at different time points.

Results showed that at 8 h time point, serum concentration of iron was significantly higher in group treated with BioIron containing BioPerine® (36.55±9.97 μg/ml) when compared to group treated with BioIron containing no BioPerine®.

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Clinical Study

In an open-label, non-randomized study, 30 subjects were provided with BioIron™ tablet (containing 8.5 mg of elemental iron and 2.5 mg of BioPerine® ) twice a day as a dietary supplement for a period of 56 days.

It was evident that treatment of iron deficiency anemia with BioIron™ for 56 days showed a statistically significant increase in hematologic values. Blood hemoglobin level was improved significantly. A significant improvement in serum iron (could be correlated to the immediate release of iron from BioIron™ into the systemic circulation); total iron binding capacity and serum ferritin level was also observed (Fig. 1 and 2).


Overall, BioIron™ was safe and effective in the management of iron deficiency anemia without any adverse events.

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About Sabinsa

Sabinsa Corporation is a manufacturer, supplier and marketer of herbal extracts, cosmeceuticals, minerals, dietary supplements and specialty fine chemicals for the nutritional, cosmetic, pharmaceutical and food industries.
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Sabinsa Corporation

20 Lake Drive 

East Windsor

NJ 08520, USA

Tel: +1 732 777 1111

Fax: +1 732 777 1443

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