Co Q₁₀ - PHARMACOKINETIC EVALUATION unique difficulties:

* Slow absorption from GI tract
* Enterohepatic recycling
* Endogenous Co Q₁₀ production

 

Co Q₁₀ - PHARMACOKINETIC MODEL

X0 : Gastrointestinal compartment
X1 : Plasma chylomicrons and the tissues where rapid distribution can take place
X2 : Liver
X3 : VLDL and tissues which are rapidly accessible to Co Q₁₀

Plasma concentration of Co Q₁₀ = X1 + X3

Pharmacokinetics of Coenzyme Q₁₀. The increase in blood levels following a single oral intake of Coenzyme Q₁₀ (90 mg) with and without Bioperine® (5mg)


Time of assay after a single dose administration of Coenzyme Q₁₀

 

 

Absolute change in serum Coenzyme Q₁₀ after 14 days supplementation of Coenzyme Q₁₀ (90mg/day) with and without Bioperine® (5mg/day)

Effect of Bioperine® on serum CoQ₁₀ levels during a 21 day supplementation trial.

Mean serum CoQ₁₀ AUC values following supplementation of 120 mg of CoQ₁₀ with and without 5 mg of Bioperine®